@article{186261,
  keywords = {Humans, Gene Library, Female, Cell Movement, RNA, Small Interfering, Breast Neoplasms, Gene Expression Regulation, Neoplastic, Neoplasm Invasiveness, Protein Stability, Proteolysis, Neoplasm Metastasis, Snail Family Transcription Factors, Ubiquitination, Ubiquitin Thiolesterase},
  author = {Wenyang Li and Minhong Shen and Yi-Zhou Jiang and Ruina Zhang and Hanqiu Zheng and Yong Wei and Zhi-Ming Shao and Yibin Kang},
  title = {Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2},
  abstract = {<p>SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability. Further investigation of USP20 demonstrated its function in promoting migration, invasion, and metastasis of breast cancer. USP20 positively correlates with SNAI2 protein level in breast tumor samples, and higher USP20 expression is associated with poor prognosis in ER breast cancer patients.</p>
},
  year = {2020},
  journal = {Genes Dev},
  volume = {34},
  pages = {1310-1315},
  month = {10/2020},
  issn = {1549-5477},
  doi = {10.1101/gad.339804.120},
  language = {eng},
}