@article{186286,
  keywords = {Animals, Humans, developmental biology, Biomedical Research, Cell Movement, Neoplasms, Epithelial-Mesenchymal Transition, Terminology as Topic, Cell Plasticity, Consensus},
  author = {Jing Yang and Parker Antin and Geert Berx and C{\'e}dric Blanpain and Thomas Brabletz and Marianne Bronner and Kyra Campbell and Amparo Cano and Jordi Casanova and Gerhard Christofori and Shoukat Dedhar and Rik Derynck and Heide Ford and Jonas Fuxe and de Antonio Garc{\'\i}a Herreros and Gregory Goodall and Anna-Katerina Hadjantonakis and Ruby Huang and Chaya Kalcheim and Raghu Kalluri and Yibin Kang and Yeesim Khew-Goodall and Herbert Levine and Jinsong Liu and Gregory Longmore and Sendurai Mani and Joan Massagu{\'e} and Roberto Mayor and David McClay and Keith Mostov and Donald Newgreen and Angela Nieto and Alain Puisieux and Raymond Runyan and Pierre Savagner and Ben Stanger and Marc Stemmler and Yoshiko Takahashi and Masatoshi Takeichi and Eric Theveneau and Jean Paul Thiery and Erik Thompson and Robert Weinberg and Elizabeth Williams and Jianhua Xing and Binhua Zhou and Guojun Sheng and EMT International Association (TEMTIA)},
  title = {Guidelines and definitions for research on epithelial-mesenchymal transition},
  abstract = {<p>Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by {\textquoteright}the EMT International Association{\textquoteright} (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.</p>
},
  year = {2020},
  journal = {Nat Rev Mol Cell Biol},
  volume = {21},
  pages = {341-352},
  month = {06/2020},
  issn = {1471-0080},
  doi = {10.1038/s41580-020-0237-9},
  language = {eng},
}