@article{204241,
  keywords = {Primary},
  author = {Mark Esposito and Cao Fang and Yong Wei and Alfonso Pozzan and Claudia Beato and Xiaoyang Su and Josiah Hutton and Tavis Reed and Xiang Hang and Enrico Perini and Wen Wang and Xiaobing Cheng and Yan Pan and Jianshi Yu and Maureen Kane and Malini Manoharan and John Proudfoot and Ileana Cristea and Yibin Kang},
  title = {Development of retinoid nuclear receptor pathway antagonists through targeting aldehyde dehydrogenase 1A3.},
  abstract = {<p>Aldehyde dehydrogenase 1a3 (ALDH1A3) activity is recognized as a pathogenic trait in cardiometabolic diseases and cancer, though the mechanisms by which ALDH1A3 promotes disease are unclear and effective therapeutic inhibitors of ALDH1A3 are lacking. Whereas the function of the ALDH1A enzymes in development is the conversion of retinaldehyde into all- retinoic acid (atRA) to activate retinoid nuclear receptor signaling, this pathway is paradoxically hypothesized as a cell-intrinsic tumor suppressor pathway. We resolve this paradox by showing that while ALDH1A3 is overexpressed across diverse cancers, ALDH1A3-expressing tumor cells lose sensitivity to retinoid signaling. Instead, atRA produced by ALDH1A3 acts in a paracrine fashion to activate retinoid nuclear receptor signaling in immune cells to suppress anti-tumor immunity. To inhibit ALDH1A3, we developed a hybrid and high-throughput screening approach followed by medicinal optimization to identify first-in-class, oral and safe antagonists of ALDH1A3 with potent anti-tumor immunotherapeutic activity and an optimized drug development profile.</p>},
  year = {2025},
  journal = {iScience},
  volume = {28},
  pages = {113675},
  month = {11/2025},
  issn = {2589-0042},
  doi = {10.1016/j.isci.2025.113675},
  language = {eng},
}