@article{87886,
  author = {H{\'e}ctor Peinado and Haiying Zhang and Irina Matei and Bruno Costa-Silva and Ayuko Hoshino and Goncalo Rodrigues and Bethan Psaila and Rosandra Kaplan and Jacqueline Bromberg and Yibin Kang and Mina Bissell and Thomas Cox and Amato Giaccia and Janine Erler and Sachie Hiratsuka and Cyrus Ghajar and David Lyden},
  title = {Pre-metastatic niches: organ-specific homes for metastases.},
  abstract = {<p>It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the {\textquoteright}seeds{\textquoteright} of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the {\textquoteright}soil{\textquoteright} at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.</p>
},
  year = {2017},
  journal = {Nat Rev Cancer},
  volume = {17},
  pages = {302-317},
  month = {05/2017},
  issn = {1474-1768},
  doi = {10.1038/nrc.2017.6},
  language = {eng},
}