@article{87901, author = {Wei Zhuo and Yibin Kang}, title = {Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.}, abstract = {
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.
}, year = {2017}, journal = {Nat Cell Biol}, volume = {19}, pages = {81-83}, month = {01/2017}, issn = {1476-4679}, doi = {10.1038/ncb3467}, language = {eng}, }