@article{88016,
  keywords = {Animals, Drosophila, signal transduction, Mutation, Female, Actins, Cytoskeleton, Oocytes, Protein-Serine-Threonine Kinases, Epithelial Cells, Intracellular Signaling Peptides and Proteins, Drosophila Proteins, Oogenesis, Ovarian Follicle, Spectrin},
  author = {Kenneth Kin Lam Wong and Wenyang Li and Yanru An and Yangyang Duan and Zhuoheng Li and Yibin Kang and Yan Yan},
  title = {β-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.},
  abstract = {<p>Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for β-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. β-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after β-Spectrin knockdown in mammalian cells. We further demonstrated that β-spectrin mutations disrupt the basal actin network in follicle cells. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the β-spectrin mutations and the loss of the Hippo signaling activity phenotype.</p>
},
  year = {2015},
  journal = {J Biol Chem},
  volume = {290},
  pages = {6397-407},
  month = {03/2015},
  issn = {1083-351X},
  doi = {10.1074/jbc.M114.629493},
  language = {eng},
}