@article{88066,
  keywords = {Animals, Humans, Membrane Proteins, Protein Binding, Cell Proliferation, Time Factors, Phenotype, Mice, Mice, Inbred C57BL, Tumor Cells, Cultured, Female, Nuclear Proteins, Cell Line, Tumor, Genetic Predisposition to Disease, Mice, Transgenic, Breast Neoplasms, Gene Expression Regulation, Neoplastic, Neoplasm Invasiveness, Mice, Knockout, Cell Transformation, Viral, Transfection, RNA Interference, Cell Transformation, Neoplastic, Cell Adhesion Molecules, HEK293 Cells, Neoplastic Stem Cells, Mammary Glands, Animal, 9,10-Dimethyl-1,2-benzanthracene, Mammary Tumor Virus, Mouse, Medroxyprogesterone Acetate},
  author = {Liling Wan and Xin Lu and Salina Yuan and Yong Wei and Feng Guo and Minhong Shen and Min Yuan and Rumela Chakrabarti and Yuling Hua and Heath Smith and Mario Andres Blanco and Marina Chekmareva and Hao Wu and Roderick Bronson and Bruce Haffty and Yongna Xing and Yibin Kang},
  title = {MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors.},
  abstract = {<p>The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development. Mechanistically, MTDH supports the survival of mammary epithelial cells under oncogenic/stress conditions by interacting with and stabilizing Staphylococcal nuclease domain-containing 1 (SND1). Silencing MTDH or SND1 individually or disrupting their interaction compromises tumorigenenic potential of TICs in\&nbsp;vivo. This functional significance of MTDH-SND1 interaction is further supported by clinical analysis of human breast cancer samples.</p>
},
  year = {2014},
  journal = {Cancer Cell},
  volume = {26},
  pages = {92-105},
  month = {07/2014},
  issn = {1878-3686},
  doi = {10.1016/j.ccr.2014.04.027},
  language = {eng},
}