@article{88126,
  keywords = {Animals, Humans, signal transduction, Mutation, Female, Breast Neoplasms, Gene Expression Regulation, Neoplastic, Epithelial-Mesenchymal Transition, Cell Adhesion Molecules, Drug Resistance, Neoplasm, Neoplasm Metastasis, Molecular Targeted Therapy},
  author = {Liling Wan and Yibin Kang},
  title = {Pleiotropic roles of AEG-1/MTDH/LYRIC in breast cancer.},
  abstract = { Since the initial discovery of AEG-1/MTDH/LYRIC, our appreciation for this novel protein{\textquoteright}s involvement in cancer has increased dramatically over the past few years. AEG-1/MTDH/LYRIC is a key functional target of the 8q22 genomic gain that is frequently observed in poor-prognosis breast cancer, where it plays a dual role in promoting chemoresistance and metastasis. Beyond this, growing evidence from clinical research indicates a strong correlation between AEG-1/MTDH/LYRIC expression and the pathogenesis of a large spectrum of cancer types, and multiple studies employing in vitro cell culture systems and in vivo xenograft models have revealed multifaceted roles of AEG-1/MTDH/LYRIC in cancer biology, including tumor cell proliferation, apoptosis, angiogenesis, and autophagy. With increasing mechanistic understanding of AEG-1/MTDH/LYRIC, discovery of agents that can block AEG-1/MTDH/LYRIC and its regulated pathways will be beneficial to cancer patients with aberrant expression of AEG-1/MTDH/LYRIC. },
  year = {2013},
  journal = {Adv Cancer Res},
  volume = {120},
  pages = {113-34},
  issn = {0065-230X},
  doi = {10.1016/B978-0-12-401676-7.00004-8},
  language = {eng},
}