@article{88141,
  keywords = {Animals, Humans, MicroRNAs, Mice, Female, Cell Line, Tumor, Breast Neoplasms, Neoplasm Invasiveness, Up-Regulation, Gene Knockdown Techniques, Mice, Inbred BALB C, Neoplasm Metastasis, Transplantation, Heterologous, Protein Tyrosine Phosphatases, Mice, Nude},
  author = {Shuet Theng Lee and Min Feng and Yong Wei and Zhimei Li and Yuanyuan Qiao and Peiyong Guan and Xia Jiang and Chew Hooi Wong and Kelly Huynh and Jinhua Wang and Juntao Li and Murthy Karuturi and Ern Yu Tan and Dave Hoon and Yibin Kang and Qiang Yu},
  title = {Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.},
  abstract = {<p>Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Thus, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics. Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, is overexpressed in TNBC, where it supports malignant growth, invasion, and metastasis largely through modulating epidermal growth factor receptor (EGFR). We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation and inactivation, leading to EGFR up-regulation. Thus, UBASH3B may function as a crucial node in bridging multiple invasion-promoting pathways, thereby providing a potential therapeutic target for TNBC.</p>
},
  year = {2013},
  journal = {Proc Natl Acad Sci U S A},
  volume = {110},
  pages = {11121-6},
  month = {07/2013},
  issn = {1091-6490},
  doi = {10.1073/pnas.1300873110},
  language = {eng},
}