@article{88166, keywords = {Animals, Humans, MicroRNAs, Female, Breast Neoplasms, Lung Neoplasms, Monocytes, Mesenchymal Stromal Cells, Stromal Cells, Inflammation}, author = {Guangwen Ren and Yibin Kang}, title = {A one-two punch of miR-126/126* against metastasis.}, abstract = {
MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.
}, year = {2013}, journal = {Nat Cell Biol}, volume = {15}, pages = {231-3}, month = {03/2013}, issn = {1476-4679}, doi = {10.1038/ncb2703}, language = {eng}, }