@article{88171,
  keywords = {Humans, computational biology, RNA, Messenger, Transcription Factors, Cell Line, Sequence Analysis, DNA, Real-Time Polymerase Chain Reaction, Databases, Genetic, Exons, RNA-Binding Proteins, Endosomal Sorting Complexes Required for Transport, Gene Rearrangement, Chromosomes, Human, Pair 16, Chromosomes, Human, Pair 7, Gene Fusion, Mutant Chimeric Proteins, Trans-Splicing},
  author = {Wenwen Fang and Yong Wei and Yibin Kang and Laura Landweber},
  title = {Detection of a common chimeric transcript between human chromosomes 7 and 16.},
  abstract = {<p>Interchromosomal chimeric RNA molecules are often transcription products from genomic rearrangement in cancerous cells. Here we report the computational detection of an interchromosomal RNA fusion between ZC3HAV1L and CHMP1A from RNA-seq data of normal human mammary epithelial cells, and experimental confirmation of the chimeric transcript in multiple human cells and tissues. Our experimental characterization also detected three variants of the ZC3HAV1L-CHMP1A chimeric RNA, suggesting that these genes are involved in complex splicing. The fusion sequence at the novel exon-exon boundary, and the absence of corresponding DNA rearrangement suggest that this chimeric RNA is likely produced by trans-splicing in human cells.</p>
},
  year = {2012},
  journal = {Biol Direct},
  volume = {7},
  pages = {49},
  month = {12/2012},
  issn = {1745-6150},
  doi = {10.1186/1745-6150-7-49},
  language = {eng},
}