@article{88351,
  keywords = {Animals, Humans, Membrane Proteins, Neoplasms, Disease Progression, Cell Adhesion Molecules},
  author = {Guohong Hu and Yong Wei and Yibin Kang},
  title = {The multifaceted role of MTDH/AEG-1 in cancer progression.},
  abstract = {<p>Cancer is the result of the progressive acquisition of multiple malignant traits through the accumulation of genetic or epigenetic alterations. Recent studies have established a functional role of MTDH (Metadherin)/AEG-1 (Astrocyte Elevated Gene 1) in several crucial aspects of tumor progression, including transformation, evasion of apoptosis, invasion, metastasis, and chemoresistance. Overexpression of MTDH/AEG-1 is frequently observed in melanoma, glioma, neuroblastoma, and carcinomas of breast, prostate, liver, and esophagus and is correlated with poor clinical outcomes. MTDH/AEG-1 functions as a downstream mediator of the transforming activity of oncogenic Ha-Ras and c-Myc. Furthermore, MTDH/AEG-1 overexpression activates the PI3K/Akt, nuclear factor kappaB (NFkappaB), and Wnt/beta-catenin signaling pathways to stimulate proliferation, invasion, cell survival, and chemoresistance. The lung-homing domain of MTDH/AEG-1 also mediates the adhesion of tumor cells to the vasculature of distant organs and promotes metastasis. These findings suggest that therapeutic targeting of MTDH/AEG-1 may simultaneously suppress tumor growth, block metastasis, and enhance the efficacy of chemotherapeutic treatments.</p>
},
  year = {2009},
  journal = {Clin Cancer Res},
  volume = {15},
  pages = {5615-20},
  month = {09/2009},
  issn = {1078-0432},
  doi = {10.1158/1078-0432.CCR-09-0049},
  language = {eng},
}