@article{88396,
  keywords = {Animals, Humans, Transcription Factors, MicroRNAs, Neoplasms, Epithelium, Neoplasm Metastasis, Mesoderm},
  author = {Manav Korpal and Yibin Kang},
  title = {The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis.},
  abstract = {<p>MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.</p>
},
  year = {2008},
  journal = {RNA Biol},
  volume = {5},
  pages = {115-9},
  month = {07/2008},
  issn = {1555-8584},
  language = {eng},
}