@article{88401,
  keywords = {Animals, Humans, Gene Expression Profiling, Mice, Cell Line, Tumor, Genome, Human, Breast Neoplasms, Prognosis, Survival Rate, Cell Adhesion Molecules, Drug Resistance, Neoplasm, Neoplasm Metastasis, Proto-Oncogene Proteins, Mice, Nude, Xenograft Model Antitumor Assays, Proto-Oncogene Proteins c-met, Aldehyde Dehydrogenase, Chromosomes, Human, Pair 8, Neoplasm Recurrence, Local, Receptors, Growth Factor},
  author = {Guohong Hu and Robert Chong and Qifeng Yang and Yong Wei and Mario Blanco and Feng Li and Michael Reiss and Jessie Au and Bruce Haffty and Yibin Kang},
  title = {MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.},
  abstract = {<p>Targeted therapy for metastatic diseases relies on the identification of functionally important metastasis genes from a large number of random genetic alterations. Here we use a computational algorithm to map minimal recurrent genomic alterations associated with poor-prognosis breast cancer. 8q22 genomic gain was identified by this approach and validated in an extensive collection of breast tumor samples. Regional gain of 8q22 elevates expression of the metastasis gene metadherin (MTDH), which is overexpressed in more than 40\% of breast cancers and is associated with poor clinical outcomes. Functional characterization of MTDH revealed its dual role in promoting metastatic seeding and enhancing chemoresistance. These findings establish MTDH as an important therapeutic target for simultaneously enhancing chemotherapy efficacy and reducing metastasis risk.</p>
},
  year = {2009},
  journal = {Cancer Cell},
  volume = {15},
  pages = {9-20},
  month = {01/2009},
  issn = {1878-3686},
  doi = {10.1016/j.ccr.2008.11.013},
  language = {eng},
}