@article{88416,
  keywords = {Animals, Humans, Breast Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplastic Stem Cells, Bone Neoplasms, RANK Ligand},
  author = {Xin Lu and Yibin Kang},
  title = {Organotropism of breast cancer metastasis.},
  abstract = {<p>Breast cancer causes mortality by metastasizing to a variety of vital organs, such as bone, lung, brain and liver. Effective therapeutic intervention of this deadly process relies on a better mechanistic understanding of metastasis organotropism. Recent studies have confirmed earlier speculations that metastasis is a non-random process and is dependent on intricate tumor-stroma interactions at the target organ. Both the intrinsic properties of breast cancer cells and the host organ microenvironment are important in determining the efficiency of organ-specific metastasis. Advances in animal modeling, in vivo imaging and functional genomics have accelerated the discovery of important molecular mediators of organ-specific metastasis. A conceptual framework of breast cancer organotropism is emerging and will be instrumental in guiding future efforts in this exciting research field.</p>
},
  year = {2007},
  journal = {J Mammary Gland Biol Neoplasia},
  volume = {12},
  pages = {153-62},
  month = {09/2007},
  issn = {1083-3021},
  doi = {10.1007/s10911-007-9047-3},
  language = {eng},
}