@article{88466,
  keywords = {Animals, Protein Structure, Tertiary, Humans, Gene Expression Regulation, signal transduction, Promoter Regions, Genetic, Transcription Factors, Repressor Proteins, Stress, Physiological, Trans-Activators, Genes, Regulator, DNA-Binding Proteins, Smad4 Protein, Cells, Cultured, Epithelial Cells, Transforming Growth Factor beta, Smad3 Protein, Smad Proteins, Activating Transcription Factor 3, Cyclic AMP Response Element-Binding Protein, Inhibitor of Differentiation Protein 1},
  author = {Yibin Kang and Chang-Rung Chen and Joan Massagu{\'e}},
  title = {A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.},
  abstract = {<p>Genome-wide transcriptional profiling of human epithelial cells revealed that repression of Id inhibitors of differentiation (Id1, Id2, and Id3) is a general feature of the TGFbeta cytostatic program. Opposite responses of Id1 to TGFbeta and the related factor BMP are dictated by the specific ability of the TGFbeta mediator, Smad3, to activate expression of stress response factor ATF3 and then recruit this factor to the Id1 promoter. Thus, a Smad3-mediated primary gene response, ATF3 induction, enables Smad3 to participate in an ATF3-mediated, secondary gene response. As a common target of TGFbeta/Smad signals and stress signals via p38 kinase, ATF3 additionally serves to channel synergy between these pathways in the response of epithelial cells to stress and injury.</p>
},
  year = {2003},
  journal = {Mol Cell},
  volume = {11},
  pages = {915-26},
  month = {04/2003},
  issn = {1097-2765},
  language = {eng},
}