Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2
Publication Year
2020
Type
Journal Article
Abstract
SNAI2/SLUG, a metastasis-promoting transcription factor, is a labile protein that is degraded through the ubiquitin proteasome degradation system. Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability. Further investigation of USP20 demonstrated its function in promoting migration, invasion, and metastasis of breast cancer. USP20 positively correlates with SNAI2 protein level in breast tumor samples, and higher USP20 expression is associated with poor prognosis in ER breast cancer patients.
Keywords
Journal
Genes Dev
Volume
34
Issue
19-20
Pages
1310-1315
Date Published
10/2020
ISSN Number
1549-5477
Alternate Journal
Genes Dev
PMID
32943575