Role Reversal: A Pro-metastatic Function of E-Cadherin

Publication Year
2019

Type

Journal Article
Abstract

Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.

Journal
Dev Cell
Volume
51
Issue
4
Pages
417-419
Date Published
11/2019
ISSN Number
1878-1551
Alternate Journal
Dev Cell
PMID
31743661